Supported by CCR Office of Science and Technology Resources (OSTR)

Publications

Home
Research
Resources
Personnel
Media
Collaborate With Us

2024

Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells

Park JE, Kim TS, Zeng Y, Mikolaj M, Il Ahn J, Alam MS, Monnie CM, Shi V, Zhou M, Chun TW, Maldarelli F, Narayan K, Ahn J, Ashwell JD, Strebel K, Lee KS.
(2024). Nature Communications. 15(1):2017. doi: 10.1038/s41467-024-46306-8.

PubMed Link

A spatial map of hepatic mitochondria uncovers functional heterogeneity shaped by nutrient-sensing signaling

Kang SWS, Cunningham RP, Miller CB, Brown LA, Cultraro CM, Harned A, Narayan K, Hernandez J, Jenkins LM, Lobanov A, Cam M, Porat-Shliom N.
(2024 Feb 28) Nature Communications. 15(1):1799. doi: 10.1038/s41467-024-45751-9.

PubMed Link

Reconstruction via Manual and Machine-Learning Aided Segmentation of Volume EM Datasets.

Vijayakumaran A, Abuammar A, Medagedara O, Narayan K, Mennella V.
(2024) Methods Mol Biol.;2725:131-146. doi: 10.1007/978-1-0716-3507-0_8.

PubMed Link

2023

CDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cells.

Chen Z, Liu X, Kawakami M, Liu X, Baker A, Bhatawadekar A, Tyutyunyk-Massey L, Narayan K, Dmitrovsky E.
(2023 Dec 31) Cancer Biol Ther.; 24(1):2279241. doi: 10.1080/15384047.2023.2279241.

PubMed Link

Volume EM: a quiet revolution takes shape

Collinson LM, Bosch C, Bullen A, Burden JJ, Carzaniga R, Cheng C, Darrow MC, Fletcher G, Johnson E, Narayan K, Peddie CJ, Winn M, Wood C, Patwardhan A, Kleywegt GJ, Verkade P.
Nat Methods. 2023 Jun;20(6):777-782. doi: 10.1038/s41592-023-01861-8.

PubMed Link

Non-specific and specific DNA binding modes of bacterial histone, HU, separately regulate distinct physiological processes through different mechanisms

Verma, S. C., Harned, A., Narayan, K., & Adhya, S.
(2023). Molecular Microbiology. https://doi.org/10.1111/MMI.15033

PubMed Link

Instance segmentation of mitochondria in electron microscopy images with a generalist deep learning model trained on a diverse dataset

Conrad, R., & Narayan, K.
(2023). Cell Systems, 14(1), 58-71. e5. //doi.org/10.1016/J.CELS.2022.12.006

PubMed Link

2022

Delivery of ceramide phosphoethanolamine lipids to the cleavage furrow through the endocytic pathway is essential for male meiotic cytokinesis

Kunduri, G., Le, S.-H., Baena, V., Vijaykrishna, N., Harned, A., Nagashima, K., Blankenberg, D., Yoshihiro, I., Narayan, K., Bamba, T., Acharya, U., & Acharya, J. K.
(2022). PLOS Biology, 20(9), e3001599. doi.org/10.1371/journal.pbio.3001599

PubMed Link

A versatile enhanced freeze-substitution protocol for volume electron microscopy

Bélanger, S., Berensmann, H., Baena, V., Duncan, K., Meyers, B. C., Narayan, K., & Czymmek, K. J. (2022).
Frontiers in Cell and Developmental Biology, 10. doi.org/10.3389/fcell.2022.933376

PubMed Link

Volume electron microscopy

Peddie, C. J., Genoud, C., Kreshuk, A., Meechan, K., Micheva, K. D., Narayan, K., Pape, C., Parton, R. G., Schieber, N. L., Schwab, Y., Titze, B., Verkade, P., Weigel, A., & Collinson, L. M. (2022).
Nature Reviews Methods Primers, 2(1), 51. https://doi.org/10.1038/s43586-022-00131-9

PubMed Link

Intracellular connections between basal bodies promote the coordinated behavior of motile cilia

Soh AWJ, Woodhams LG, Junker AD, Enloe CM, Noren BE, Harned A, Westlake CJ, Narayan K, Oakey JS, Bayly PV, Pearson CG.
Mol Biol Cell. 2022 Sep 15:mbcE22050150. doi: 10.1091/mbc.E22-05-0150.

PubMed Link

Embedding of HIV Egress within Cortical F-Actin

Anupriya Aggarwal , Alberto Ospina Stella , Catherine C Henry , Kedar Narayan , Stuart G Turville. 
Pathogens. 2022 Jan 3;11(1):56. doi: 10.3390/pathogens11010056

PubMed Link

2021

REMBI: Recommended Metadata for Biological Images-enabling reuse of microscopy data in biology

Sarkans U, Chiu W, Collinson L, Darrow MC, Ellenberg J, Grunwald D, Hériché JK, Iudin A, Martins GG, Meehan T, Narayan K, Patwardhan A, Russell MRG, Saibil HR, Strambio-De-Castillia C, Swedlow JR, Tischer C, Uhlmann V, Verkade P, Barlow M, Bayraktar O, Birney E, Catavitello C, Cawthorne C, Wagner-Conrad S, Duke E, Paul-Gilloteaux P, Gustin E, Harkiolaki M, Kankaanpää P, Lemberger T, McEntyre J, Moore J, Nicholls AW, Onami S, Parkinson H, Parsons M, Romanchikova M, Sofroniew N, Swoger J, Utz N, Voortman LM, Wong F, Zhang P, Kleywegt GJ, Brazma A.
Nat Methods. 2021 May 21. doi: 10.1038/s41592-021-01166-8. Online ahead of print.

PubMed Link

FIB-SEM as a Volume Electron Microscopy Approach to Study Cellular Architectures in SARS-CoV-2 and Other Viral Infections: A Practical Primer for a Virologist

Baena V, Conrad R, Friday P, Fitzgerald E, Kim T, Bernbaum J, Berensmann H, Harned A, Nagashima K, Narayan K.
Viruses. 2021 Apr 2;13(4):611. doi: 10.3390/v13040611.

PubMed Link

CEM500K, a large-scale heterogeneous unlabeled cellular electron microscopy image dataset for deep learning.

Conrad R, Narayan K.
Elife. 2021 Apr 8;10:e65894. 

PubMed Link

A Workflow for High-pressure Freezing and Freeze Substitution of the Caenorhabditis elegans Embryo for Ultrastructural Analysis by Conventional and Volume Electron Microscopy.

Rahman MM, Chang IY, Cohen-Fix O, Narayan K.
Bio Protoc. 2021 Apr 5;11(7):BioProtoc.3981. eCollection 2021 Apr 5.

PubMed Link

Cryo-fluorescence microscopy of high-pressure frozen C. elegans enables correlative FIB-SEM imaging of targeted embryonic stages in the intact worm.

Chang IY, Rahman M, Harned A, Cohen-Fix O, Narayan K.
Methods Cell Biol. 2021;162:223-252. Epub 2020 Nov 4.

PubMed Link

2020

C. elegans pronuclei fuse after fertilization through a novel membrane structure.

Rahman M, Chang IY, Harned A, Maheshwari R, Amoateng K, Narayan K, Cohen-Fix O. 
Cell Biol. 2020 Feb 3;219(2).

PubMed Link

Efficient Skeleton Editing in a VR Environment Facilitates Accurate Modeling of Highly Branched Mitochondria.

Conrad, R., Ruth, T., Löffler, F., Hadlak, S., Konrad, S., Götze, C., . . . Narayan, K.  Microscopy and Microanalysis, 1-4. (2020)

Link To Paper

Enforcing Prediction Consistency Across Orthogonal Planes Significantly Improves Segmentation of FIB-SEM Image Volumes by 2D Neural Networks.

Conrad, R., Lee, H., & Narayan, K.  Microscopy and Microanalysis, 1-4. (2020)

Link To Paper

2019

Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport.

Christine Insinna, Quanlong Lu, Isabella Teixeira, Adam Harned, Elizabeth M. Semler, Jim Stauffer,Valentin Magidson, Ajit Tiwari, Anne K. Kenworthy, Kedar Narayan, and Christopher J. Westlake.
Nat Commun. 2019; 10: 428.

PubMed Link

Mitochondrial Populations Exhibit Differential Dynamic Responses to Increased Energy Demand during Exocytosis In Vivo.

Natalie Porat-Shliom, Olivia J. Harding, Lenka Malec, Kedar Narayan,and Roberto Weigert.
Science. 2019 Jan 25; 11: 440–449.

PubMed Link

2018

Extracellular vesicles direct migration by synthesizing and releasing chemotactic signals

Paul W. Kriebel, Ritankar Majumdar, Lisa M. Jenkins, Hiroshi Senoo, Weiye Wang, Sonia Ammu,Song Chen, Kedar Narayan, Miho Iijima, and Carole A. Parent. 
J Cell Biol. 2018 Aug 6; 217(8): 2891–2910.

PubMed Link

Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation.

Balagopalan L, Yi J, Nguyen T, McIntire KM, Harned AS, Narayan K, Samelson LE.
Nat Commun. 2018 May 22;9(1):2013.

PubMed Link

Deep-learning-assisted Volume Visualization.

Cheng H-C, Cardone A, Jain S, Krokos E, Narayan K, Subramaniam S and Varshney A. 
IEEE Trans Vis Comp Graph. 2018 Jan 23.

PubMed Link

2015

Focused ion beams in biology.

Narayan K and Subramaniam S.
Nat Methods. 2015 Oct 29;12(11):1021-1031.

PubMed Link

A versatile nano display platform from bacterial spore coat proteins.

Wu IL1, Narayan K2, Castaing JP1, Tian F3, Subramaniam S2, Ramamurthi KS1.  Nat Commun. 2015 Apr 9;6:6777. 

PubMed Link

Maturation of the HIV-1 core by a non-diffusional phase transition.

Frank GA, Narayan K, Bess JW, Del Prete GQ, Wu X, Moran A, Hartnell LM, Earl LA, Lifson JD, and Subramaniam S.
Nat Commun. 2015 Jan 8;6:5854.

PubMed Link

2014

Three-dimensional imaging of viral infections.

Risco C, de Castro IF, Sanz-Sanchez L, Narayan K, Grandinetti G, and Subramaniam S. 
Annu Rev Virol. 2014 Sep;1:453-73.

PubMed Link