The CMM ‘collaboratory’ is focused on using new, state-of-the-art technologies in 3-D electron microscopy for high impact biological research. We work with colleagues in CCR and elsewhere to apply these technologies to key biological problems that require high resolution, 3-D imaging by electron microscopy.
The ‘collaboratory’ research is divided into two areas: molecular imaging by high resolution cryo-electron microscopy (cryo-EM), and cellular volume electron microscopy (volume EM). Research in the ‘collaboratory’ is primarily driven by biological questions, but is supported by complementary research into methods and new technologies for high resolution imaging with electron microscopy.
Primary areas of research interest for the cryo-EM section include structure determination of membrane integral and small protein complexes involved in signaling and cancer metabolism. The volume EM section focuses on the ultrastructure of cells and tissues, with an emphasis on cell-cell interactions, cell division, and structural aspects of cellular metabolism.